Neuroplasticity lab.
Exploring the function of sleep in shaping neural circuitry
Our science
We explore mechanisms that gate plasticity to reshape cortical circuits through experience and learning, while maintaining normal brain function. The central aim of this research is to use the knowledge on cortical restructuring to develop strategies for targeted interventions that enhance plasticity. Thus, our work has important implications not only for the healthy but also for the diseased or impaired nervous system.
Learning and Experience
We aim to understand how learning restructures cortical circuits and influences sensory processing.
Sleep
Our research investigates the impact of specific sleep stages on the restructuring of sensory pathways.
Neuromodulation
We focus on the role of neuromodulators in plasticity and gating of neuronal circuits, investigating the effects of combinatorial neuromodulatory stimulation to promote restructuring of cortical circuits.
Research Methodologies
We study learning-related changes in sensory processing of mice undergoing behavioral training. We use a combination of optical and electrophysiological methods to record neuronal activity combined with optogenetic manipulations of specific neuron types or optically targeted neurons. This includes behavior, combined two-photon or widefield imaging and optogenetics, pharmacological tools, and consecutive in vitro circuit analysis.